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Cyp1a2/Cyp1a1tm1.1Bra
Targeted Allele Detail
Nomenclature
Symbol: Cyp1a2/Cyp1a1tm1.1Bra
Name: cytochrome P450, family 1, subfamily a, polypeptide 1; targeted mutation 1.1, Christopher A Bradfield
MGI ID: MGI:3840319
Synonyms: Cyp1a1/Cyp1a2tm1.1Bra, DREC-
Gene: Cyp1a1  Location: Chr9:57687928-57703824 bp, + strand  Genetic Position: Chr9, 31.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:147150
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsAn frt flanked neo cassette followed by a loxP site were inserted upstream and a second loxP site was inserted downstream of a cluster of 7 dioxin responsive elements (DRE). These DREs regulate expression of both Cyp1a1 and Cyp1a2. The neo cassette and DRE cluster were then removed by Flp and Cre mediated recombination respectively. (J:147150)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp1a1 Mutation:  16 strains or lines available
References
Original:  J:147150 Nukaya M, et al., The role of the dioxin-responsive element cluster between the Cyp1a1 and Cyp1a2 loci in aryl hydrocarbon receptor biology. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4923-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory