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| Caption | Generation of the MGI:3840320 allele. (A) Genomic structure of mouse Cyp1a1 and Cyp1a2 genes on chromosome 9. The Cyp1a1-Cyp1a2 junction region contains 8 consensus DRE sequences (vertical bars, DREs 1-8). The DREC containing 7 of these DREs (DREs 1-7) is located in the enhancer upstream region of the Cyp1a1 gene within approximately 1.4 kb of the transcriptional start site. Open box, exon 1 of Cyp1a1 or Cyp1a2; closed box, exon 2 of Cyp1a1 and Cyp1a2. (B) Targeting strategy for excision of DREC. White arrowhead, lox-P sites; black arrowhead, frt sites; bold line, Cyp1a1 proximal promoter; Neo, neomycin-resistant gene cassette; N, NcoI; SL, SalI; SII, SacII; SS, SspI site. (C) Genotyping strategies for WT, DRECfxneo, DRECfx, and DREC null (MGI:3840320) alleles. | ||||
| Copyright | This image is from Nukaya M, Proc Natl Acad Sci U S A 2009 Mar 24;106(12):4923-8. Copyright 2009 National Academy of Sciences, U.S.A. J:147150 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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