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Gene trapped Allele Detail
Symbol: Prkab1Gt(RRR454)Byg
Name: protein kinase, AMP-activated, beta 1 non-catalytic subunit; gene trap RRR454, BayGenomics
MGI ID: MGI:3838355
Synonyms: AMPKbeta1-
Gene: Prkab1  Location: Chr5:116151645-116162567 bp, - strand  Genetic Position: Chr5, 56.1 cM, cytoband F
Mutant Cell Line:  RRR454
Germline Transmission:  Earliest citation of germline transmission: J:146618
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0Lxf     Vector Type: gene trap
Mutation detailsThe gene trap vector, which contains a beta-geo cassette, inserted downstream of exon 5. The fusion product lacks the terminal 46 animo acids required to form the active heterodimer. The absence of endogenous protein expression but expression of the lacZ fusion transcript was confirmed by western blot analysis on mouse embryonic fibroblasts and a variety of tissues, respectively. (J:146618)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkab1 Mutation:  18 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
Original:  J:146618 Dasgupta B, et al., AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Dev Cell. 2009 Feb;16(2):256-70
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
The Jackson Laboratory