Syne1^tm1Mcn
Targeted Allele Detail

Summary

• Symbol: Syne1^tm1Mcn
• Name: spectrin repeat containing, nuclear envelope 1; targeted mutation 1, Elizabeth M McNally
• MGI ID: MGI:3834365
• Gene: Syne1 Location: Chr10:4970917-5501482 bp, - strand Genetic Position: Chr10, 2.01 cM, cytoband A1
• Alliance: Syne1^tm1Mcn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144757
• Parent Cell Line: PRX-129S6 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of the last coding exon, and an additional loxP site was inserted downstream of the last coding exon. This exon encodes the transmembrane domain and short luminal sequence that contribute to the KASH domain. (J:144757)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syne1 Mutation: 202 strains or lines available

References

• Original: J:144757 Puckelwartz MJ, et al., Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice. Hum Mol Genet. 2009 Feb 15;18(4):607-20
• All: 1 reference(s)