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Targeted Allele Detail
Symbol: Lyz2tm1(DTR)Mtka
Name: lysozyme 2; targeted mutation 1, Masato Tanaka
MGI ID: MGI:3834185
Synonyms: LysM-DTR
Gene: Lyz2  Location: Chr10:117113446-117118177 bp, - strand  Genetic Position: Chr10, 65.34 cM
Alliance: Lyz2tm1(DTR)Mtka page
Germline Transmission:  Earliest citation of germline transmission: J:145285
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was replaced with a cDNA for human diphtheria toxin receptor, heparin-binding epidermal growth factor-like growth factor (HB-EGF), and a floxed neo cassette. (J:145285)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lyz2 Mutation:  28 strains or lines available
Original:  J:145285 Miyake Y, et al., Protective role of macrophages in noninflammatory lung injury caused by selective ablation of alveolar epithelial type II Cells. J Immunol. 2007 Apr 15;178(8):5001-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory