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Plac8tm1Bhk
Targeted Allele Detail
Nomenclature
Symbol: Plac8tm1Bhk
Name: placenta-specific 8; targeted mutation 1, Beverly H Koller
MGI ID: MGI:3834141
Synonyms: Onzin-
Gene: Plac8  Location: Chr5:100701591-100720111 bp, - strand  Genetic Position: Chr5, 48.49 cM, cytoband E3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145277
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA portion of intron 3 and exon 4 was replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on intestine, spleen, and neutrophil extracts. (J:145277)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plac8 Mutation:  14 strains or lines available
References
Original:  J:145277 Ledford JG, et al., Impaired host defense in mice lacking ONZIN. J Immunol. 2007 Apr 15;178(8):5132-43
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory