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Targeted Allele Detail
Symbol: Il17ftm1Awai
Name: interleukin 17F; targeted mutation 1, Ari Waisman
MGI ID: MGI:3833572
Synonyms: IL-17f-
Gene: Il17f  Location: Chr1:20777146-20785274 bp, - strand  Genetic Position: Chr1, 6.49 cM
Germline Transmission:  Earliest citation of germline transmission: J:144710
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA cassette containing a lacZ reporter gene and a floxed neomycin cassette replaced parts of exon 2 and 3 of the gene locus. Gene inactivation was confirmed by a lack of protein detectable by ELISA on the supernatant of Th17 polarized splenocytes. (J:144710)
Gene-targeting strategy for the generation of the Il17ftm1Awai allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il17f Mutation:  10 strains or lines available
Original:  J:144710 Haak S, et al., IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J Clin Invest. 2009 Jan;119(1):61-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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