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Il17ftm1Awai
Targeted Allele Detail
Nomenclature
Symbol: Il17ftm1Awai
Name: interleukin 17F; targeted mutation 1, Ari Waisman
MGI ID: MGI:3833572
Synonyms: IL-17f-
Gene: Il17f  Location: Chr1:20777146-20790617 bp, - strand  Genetic Position: Chr1, 6.49 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144710
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA cassette containing a lacZ reporter gene and a floxed neomycin cassette replaced parts of exon 2 and 3 of the gene locus. Gene inactivation was confirmed by a lack of protein detectable by ELISA on the supernatant of Th17 polarized splenocytes. (J:144710)
Gene-targeting strategy for the generation of the Il17ftm1Awai allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il17f Mutation:  10 strains or lines available
References
Original:  J:144710 Haak S, et al., IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J Clin Invest. 2009 Jan;119(1):61-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory