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Dvl3tm1Awb
Targeted Allele Detail
Nomenclature
Symbol: Dvl3tm1Awb
Name: dishevelled segment polarity protein 3; targeted mutation 1, Anthony Wynshaw-Boris
MGI ID: MGI:3831892
Gene: Dvl3  Location: Chr16:20335732-20352760 bp, + strand  Genetic Position: Chr16, 12.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142392
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment spanning from part of exon 2 through exon 7 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on E13.5 whole embryo extracts. (J:142392)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 18 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dvl3 Mutation:  31 strains or lines available
References
Original:  J:142392 Etheridge SL, et al., Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet. 2008 Nov;4(11):e1000259
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory