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Tph1tm2Lex
Targeted Allele Detail
Nomenclature
Symbol: Tph1tm2Lex
Name: tryptophan hydroxylase 1; targeted mutation 2, Lexicon Pharmaceuticals
MGI ID: MGI:3831653
Gene: Tph1  Location: Chr7:46644641-46672537 bp, - strand  Genetic Position: Chr7, 30.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144582
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exon 2 was replaced with a neo cassette. (J:144582)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tph1 Mutation:  18 strains or lines available
References
Original:  J:144582 Savelieva KV, et al., Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS One. 2008;3(10):e3301
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory