Phenotypes associated with this allele

• Allele Symbol: Tph1^tm2Lex
• Allele Name: targeted mutation 2, Lexicon Pharmaceuticals
• Allele ID: MGI:3831653
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tph1^tm2Lex/Tph1^tm2Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3831673
cx2	Tph1^tm2Lex/Tph1^tm2Lex Tph2^tm1Lex/Tph2^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3831675

Genotype
MGI:3831673

hm1

• Allelic Composition: Tph1^tm2Lex/Tph1^tm2Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal serotonin level ( J:144582 )

• the levels of 5-HT in the blood, jejunum, and colon are decreased compared to in wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:144582 )

N • mice exhibit normal behavior

Genotype
MGI:3831675

cx2

• Allelic Composition: Tph1^tm2Lex/Tph1^tm2Lex; Tph2^tm1Lex/Tph2^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

behavior/neurological

abnormal emotion/affect behavior ( J:144582 )

• mice exhibit less immobility and more struggling in a forced swim experiment compared to wild-type mice

• mice exhibit increased immobility in a tail suspension test compared to wild-type mice

abnormal response to novel object ( J:144582 )

• mice burry more marbles in a novelty-induced digging assay compared to wild-type mice

decreased thermal nociceptive threshold ( J:144582 )

growth/size/body

decreased body weight ( J:144582 )

• in males

decreased body length ( J:144582 )

• in males

homeostasis/metabolism

decreased serotonin level ( J:144582 )

• serotonin levels are reduced in the brain from 94% (cerebellum) to 99% (cortex) compared to in wild-type mice

• serotonin levels in peripheral tissues are decreased compared to in wild-type mice

adipose tissue

decreased percent body fat/body weight ( J:144582 )

• in males and females