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Nodaltm2Mku
Targeted Allele Detail
Nomenclature
Symbol: Nodaltm2Mku
Name: nodal; targeted mutation 2, Michael R Kuehn
MGI ID: MGI:3830289
Synonyms: Nodalfl2
Gene: Nodal  Location: Chr10:61253751-61261117 bp, + strand  Genetic Position: Chr10, 32.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142430
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxp site was inserted into intron 1 and a floxed PGK-neo cassette was inserted into the 3' UTR via homologous recombination. The PGK-neo cassette was then removed by in-vitro Cre-mediated recombination. (J:142430)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nodal Mutation:  38 strains or lines available
References
Original:  J:142430 Kumar A, et al., Broad mesodermal and endodermal deletion of Nodal at postgastrulation stages results solely in left/right axial defects. Dev Dyn. 2008 Dec;237(12):3591-601
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory