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Il23atm1.1Thak
Targeted Allele Detail
Nomenclature
Symbol: Il23atm1.1Thak
Name: interleukin 23, alpha subunit p19; targeted mutation 1.1, Paresh Thakker
MGI ID: MGI:3830062
Synonyms: P19-
Gene: Il23a  Location: Chr10:128296140-128298084 bp, - strand  Genetic Position: Chr10, 76.51 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143970
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated deletion of the first four exons of the gene locus was achieved by transient expression of cre recombinase in fertilized oocytes that were heterozygote for the Il23atm1Thak allele. This created a null allele as determined by Southern blotting. (J:143970)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il23a Mutation:  9 strains or lines available
Notes
ES cell line = TG-ES01-02 (Eurogentec)
References
Original:  J:143970 Thakker P, et al., IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis. J Immunol. 2007 Feb 15;178(4):2589-98
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory