Il23a^tm1.1Thak
Targeted Allele Detail

Summary

• Symbol: Il23a^tm1.1Thak
• Name: interleukin 23, alpha subunit p19; targeted mutation 1.1, Paresh Thakker
• MGI ID: MGI:3830062
• Synonyms: P19^-
• Gene: Il23a Location: Chr10:128132009-128133953 bp, - strand Genetic Position: Chr10, 76.51 cM, cytoband D3
• Alliance: Il23a^tm1.1Thak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143970
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated deletion of the first four exons of the gene locus was achieved by transient expression of cre recombinase in fertilized oocytes that were heterozygote for the Il23a^tm1Thak allele. This created a null allele as determined by Southern blotting. (J:143970)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il23a Mutation: 25 strains or lines available

Notes

ES cell line = TG-ES01-02 (Eurogentec); same line as B6-2

References

• Original: J:143970 Thakker P, et al., IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitis. J Immunol. 2007 Feb 15;178(4):2589-98
• All: 2 reference(s)