Analysis Tools
immune system
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• T cells from draining lymph nodes of MOG-immunized mice proliferate less in vitro when cultured with MOG peptide
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• T cells from draining lymph nodes of MOG-immunized mice produce much less IFN-gamma in vitro when cultured with MOG peptide
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• T cells from draining lymph nodes of MOG-immunized mice produce much less IL-17A in vitro when cultured with MOG peptide
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• mice do not develop EAE when immunized with MOG peptide compared to controls that develop a robust disease
• a less severe disease with later onset occurs to wild-type mice when they are recipients of CD4+ T cells isolated from MOG-immunized mice
• however, mutant mice are susceptible to EAE when they are recipients of activated CD4+ T cells isolated from MOG-immunized wild-type mice with slightly less inflammation occurring in the cervical and thoracic spinal cord
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hematopoietic system
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• T cells from draining lymph nodes of MOG-immunized mice proliferate less in vitro when cultured with MOG peptide
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cellular
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• T cells from draining lymph nodes of MOG-immunized mice proliferate less in vitro when cultured with MOG peptide
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