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Il17ftm1Yiw
Targeted Allele Detail
Nomenclature
Symbol: Il17ftm1Yiw
Name: interleukin 17F; targeted mutation 1, Yoichiro Iwakura
MGI ID: MGI:3830035
Synonyms: IL-17F
Gene: Il17f  Location: Chr1:20777146-20790617 bp, - strand  Genetic Position: Chr1, 6.49 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143719
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis gene locus lies within 60 kb of the highly homologous gene locus Il17A. In order to generate a double mutant, ES cells heterozygote for the Il17atm1Yiw null allele were retargeted with a second vector to the Il17f locus. A hygromycin resistance gene replaced exons 2 and 3 of the allele that was in trans with the Il17atm1Yiw allele. The two mutant loci were bred apart and gene inactivation of just the Il17f allele was confirmed by RT-PCR of activated splenocytes collected from homozygote mice. (J:143719)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il17f Mutation:  10 strains or lines available
References
Original:  J:143719 Ishigame H, et al., Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009 Jan;30(1):108-19
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory