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Targeted Allele Detail
Symbol: Il17ftm1Yiw
Name: interleukin 17F; targeted mutation 1, Yoichiro Iwakura
MGI ID: MGI:3830035
Synonyms: IL-17F
Gene: Il17f  Location: Chr1:20777146-20785274 bp, - strand  Genetic Position: Chr1, 6.49 cM
Germline Transmission:  Earliest citation of germline transmission: J:143719
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis gene locus lies within 60 kb of the highly homologous gene locus Il17A. In order to generate a double mutant, ES cells heterozygote for the Il17atm1Yiw null allele were retargeted with a second vector to the Il17f locus. A hygromycin resistance gene replaced exons 2 and 3 of the allele that was in trans with the Il17atm1Yiw allele. The two mutant loci were bred apart and gene inactivation of just the Il17f allele was confirmed by RT-PCR of activated splenocytes collected from homozygote mice. (J:143719)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il17f Mutation:  10 strains or lines available
Original:  J:143719 Ishigame H, et al., Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity. 2009 Jan;30(1):108-19
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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