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Targeted Allele Detail
Symbol: Adartm1.1Phs
Name: adenosine deaminase, RNA-specific; targeted mutation 1.1, Peter H Seeburg
MGI ID: MGI:3828307
Synonyms: Adarf, adarf7-9
Gene: Adar  Location: Chr3:89622329-89660753 bp, + strand  Genetic Position: Chr3, 39.19 cM, cytoband F2
Germline Transmission:  Earliest citation of germline transmission: J:142338
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo selection cassette was placed upstream of exon 7 in the SmaI restriction site and an additional loxP site was inserted downstream of exon 9. Correct targeting was confirmed by genomic PCR. LoxP-flanked (floxed) sequence encoded residues 707?870 of the interferon-inducible form of ADAR1 (GenBankTM/EBI accession number AAK16102), including essential regions for editing activity. (J:87715)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Adar Mutation:  58 strains or lines available
Original:  J:142338 Hartner JC, et al., ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling. Nat Immunol. 2009 Jan;10(1):109-15
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory