Myh11tm2Peri
Targeted Allele Detail
|
Symbol: |
Myh11tm2Peri |
Name: |
myosin, heavy polypeptide 11, smooth muscle; targeted mutation 2, Muthu Periasamy |
MGI ID: |
MGI:3821724 |
Synonyms: |
SM2- |
Gene: |
Myh11 Location: Chr16:14012392-14109227 bp, - strand Genetic Position: Chr16, 9.71 cM
|
Alliance: |
Myh11tm2Peri page
|
|
Myh11tm2Peri/Myh11tm2Peri mice exhibit segmental distention of alimentary tract, retention of urine in renal pelvis/bladder and development of end-stage hydronephrosis
Show the 2 phenotype image(s) involving this allele.
|
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:142230
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
129
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: Exon 41 was replaced with a neo cassette. The absence of isoform SM2 and reduced presence of isoform SM1 was confirmed by western blot analysis on bladder extracts.
(J:142230)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Myh11 Mutation: |
93 strains or lines available
|
|
Original: |
J:142230 Chi M, et al., Ablation of smooth muscle myosin heavy chain SM2 increases smooth muscle contraction and results in postnatal death in mice. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18614-8 |
All: |
1 reference(s) |
|