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Targeted Allele Detail
Symbol: Telo2tm1.1Tdl
Name: telomere maintenance 2; targeted mutation 1.1, Titia de Lange
MGI ID: MGI:3819391
Synonyms: Tel2DEL
Gene: Telo2  Location: Chr17:25099570-25115967 bp, - strand  Genetic Position: Chr17, 12.53 cM, cytoband A3.3
Germline Transmission:  Earliest citation of germline transmission: J:141633
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsTransient cre expression in ES cells was used to remove the floxed exon 3 and the neo cassette. This deletion results in a frame shift and premature termination of translation at amino acid 168 of 840. A two-fold reduction in protein expression levels was confirmed by western blot analysis on embryonic fibroblasts heterozygous for the allele. (J:141633)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Telo2 Mutation:  5 strains or lines available
Original:  J:141633 Takai H, et al., Tel2 regulates the stability of PI3K-related protein kinases. Cell. 2007 Dec 28;131(7):1248-59
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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