Tg(Myh11-icre/ERT2)1Soff
Transgene Detail
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Symbol: |
Tg(Myh11-icre/ERT2)1Soff |
Name: |
transgene insertion 1, Stefan Offermanns |
MGI ID: |
MGI:3819270 |
Synonyms: |
Myh11-CreERT2-Off, SMCCre, SMMHC-CreERT2, Tg(Myh11-cre/ERT2)1Soff, Tg(Myh11-cre/ESR1)1Soff |
Transgene: |
Tg(Myh11-icre/ERT2)1Soff Location: unknown Genetic Position: ChrY, Syntenic
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Alliance: |
Tg(Myh11-icre/ERT2)1Soff page
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Transgene Type: |
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Transgenic (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Tg(Myh11-icre/ERT2)1Soff expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Myh11 (MGI:102643) |
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Mutation details: The mouse promoter from BAC clone 26630 was used to drive inducible icre expression in smooth muscle cells. An frt-flanked beta-lactamase gene contained within the cre/ESR1 cassette was removed by flp mediated recombination prior to micro-injection into fertilized oocytes. No line information was given.
(J:141641, J:148424)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Myh11
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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Original: |
J:141641 Wirth A, et al., G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med. 2008 Jan;14(1):64-8 |
All: |
244 reference(s) |
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