Nampt^tm1Oleo
Targeted Allele Detail

Summary

• Symbol: Nampt^tm1Oleo
• Name: nicotinamide phosphoribosyltransferase; targeted mutation 1, Oberdan Leo
• MGI ID: MGI:3818627
• Synonyms: Nampt^flox
• Gene: Nampt Location: Chr12:32870334-32903368 bp, + strand Genetic Position: Chr12, 13.74 cM, cytoband B1
• Alliance: Nampt^tm1Oleo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141448
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted upstream of exon 5 and an additional loxP site was inserted downstream of exon 6. Germ line, flp mediated recombination was used to remove the neo cassette leaving exons 5 and 6 floxed. (J:141448)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nampt Mutation: 91 strains or lines available

References

• Original: J:141448 Rongvaux A, et al., Nicotinamide phosphoribosyl transferase/pre-B cell colony-enhancing factor/visfatin is required for lymphocyte development and cellular resistance to genotoxic stress. J Immunol. 2008 Oct 1;181(7):4685-95
• All: 20 reference(s)