Igf1rtm1Jcbr
Targeted Allele Detail
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Symbol: |
Igf1rtm1Jcbr |
Name: |
insulin-like growth factor I receptor; targeted mutation 1, Jens C Bruning |
MGI ID: |
MGI:3818453 |
Synonyms: |
IGF-1Rflox |
Gene: |
Igf1r Location: Chr7:67602575-67883416 bp, + strand Genetic Position: Chr7, 37.27 cM
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Alliance: |
Igf1rtm1Jcbr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:141321
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site and an FRT flanked neomycin resistance gene were placed in intron 2. A second loxP site was inserted just 3' of exon 3. Cre excision of exon 3 will result in a frame shift after codon 213, 27 additional codons and then a stop codon in exon 4. Chimeric animals were bred with a Flpe deleter mouse with a C57BL/6 background to remove the neomycin reporter.
(J:141321)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Igf1r Mutation: |
86 strains or lines available
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Original: |
J:141321 Kloting N, et al., Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth. Diabetes. 2008 Aug;57(8):2074-82 |
All: |
29 reference(s) |
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