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Chemically induced Allele Detail
Symbol: Leprm3Btlr
Name: leptin receptor; mutation 3, Bruce Beutler
MGI ID: MGI:3817472
Synonyms: well-upholstered
Gene: Lepr  Location: Chr4:101717404-101815352 bp, + strand  Genetic Position: Chr4, 46.96 cM
Strain of Origin:  C57BL/6J
Project Collection: Beutler Mutagenetix
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsThis mutation, identified by its phenotype among G3 progeny of an ENU mutagenized male mouse, is a G to A transition at nucleotide position 2421 (variant 1; Genbank accession NM_146146), in the 12th of the gene's 18 exons. It results in the replacement of a tryptophan codon at amino acid position 623 by a stop codon (W623Ter), which truncates the receptor by 539 amino acids at its C terminus. (J:140985)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  76 strains or lines available
Original:  J:140985 Siggs OM, et al., Record for "well-upholstered", updated November 13, 2008. MGI Direct Data Submission. 2008;
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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