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Gene trapped Allele Detail
Symbol: DymGt(GTR1.3)1Rul
Name: dymeclin; gene trap 1, H Earl Ruley
MGI ID: MGI:3817312
Gene: Dym  Location: Chr18:75018772-75286966 bp, + strand  Genetic Position: Chr18, 50.97 cM, cytoband E2
DymGt(GTR1.3)1Rul/DymGt(GTR1.3)1Rul mice display growth plate abnormalities

Show the 5 phenotype image(s) involving this allele.

Mutant Cell Line:  b3p1h1 (H Earl Ruley)
Germline Transmission:  Earliest citation of germline transmission: J:141099
Parent Cell Line:  AC1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: pGTR1.3
Mutation detailsThe retrovirus gene trap vector GTR1.3 containing a puro gene, a lacZ gene, a Pol2 gene and a neo cassette was inserted into intron 16. The fusion transcript lacks exon 17 and encodes a fusion protein that replaces the last 49 amino acids with 137 irrelevant residues. (J:137511, J:141099)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dym Mutation:  65 strains or lines available
Original:  J:141099 Osipovich AB, et al., Dyggve-Melchior-Clausen syndrome: chondrodysplasia resulting from defects in intracellular vesicle traffic. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16171-6
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory