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Targeted Allele Detail
Symbol: Batf3tm1Kmm
Name: basic leucine zipper transcription factor, ATF-like 3; targeted mutation 1, Kenneth M Murphy
MGI ID: MGI:3817232
Gene: Batf3  Location: Chr1:190830611-190841140 bp, + strand  Genetic Position: Chr1, 96.28 cM, cytoband H6
Alliance: Batf3tm1Kmm page
Germline Transmission:  Earliest citation of germline transmission: J:141064
Parent Cell Line:  MC50 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1-2 were replaced by a floxed neomycin cassette. Cre-mediated recombination removed the neo cassette. Gene inactivation was confirmed by a lack of protein detected by immunoblot analysis of Th1 CD4+ T cells. (J:141064)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Batf3 Mutation:  17 strains or lines available
Original:  J:141064 Hildner K, et al., Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science. 2008 Nov 14;322(5904):1097-100
All:  198 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory