About   Help   FAQ
Cbfa2t3tm1.1Swh
Targeted Allele Detail
Nomenclature
Symbol: Cbfa2t3tm1.1Swh
Name: CBFA2/RUNX1 translocation partner 3; targeted mutation 1.1, Scott W Hiebert
MGI ID: MGI:3815201
Synonyms: Mtg16-
Gene: Cbfa2t3  Location: Chr8:122625141-122699109 bp, - strand  Genetic Position: Chr8, 71.93 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140967
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCbfa2t3tm1Swh heterozygotes were crossed with transgenic cre mice resulting in excision of exon 8 from the germline. It was predicted to be a null allele because splicing from exon 7 to exon 9 introduces a stop codon and would trigger nonsense-mediated mRNA decay. Gene inactivation in homozygotes was confirmed by a lack of signal in immunoblot assays of splenocyte nuclear extracts. (J:140967)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cbfa2t3 Mutation:  2 strains or lines available
References
Original:  J:140967 Chyla BJ, et al., Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation. Mol Cell Biol. 2008 Oct;28(20):6234-47
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/11/2020
MGI 6.14
The Jackson Laboratory