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Agrptm1(cre)Lowl
Targeted Allele Detail
Nomenclature
Symbol: Agrptm1(cre)Lowl
Name: agouti related neuropeptide; targeted mutation 1, Bradford B Lowell
MGI ID: MGI:3815085
Synonyms: Agrp-Cre, Agrp-Ires-cre
Gene: Agrp  Location: Chr8:105566695-105579845 bp, - strand  Genetic Position: Chr8, 53.04 cM, cytoband D1-D2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140858
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsAn IRES-cre-frt-kan/neo-frt cassette was inserted in frame in exon 3 after the stop codon via homologous recombination. The kan/neo cassette was subsequently removed via in vivo Flp mediated recombination. Crosses to reporter mice detected Cre activity in AGRP+ neurons. (J:140858)
Recombinase
activity
Activity:
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Driver: Agrp     Summary of all recombinase alleles driven by Agrp. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Agrp Mutation:  15 strains or lines available
References
Original:  J:140858 Tong Q, et al., Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008 Sep;11(9):998-1000
All:  84 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory