All Phenotypes Agrp<tm1(cre)Lowl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Agrp^tm1(cre)Lowl
targeted mutation 1, Bradford B Lowell
MGI:3815085

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rock1^tm1.1Itl/Rock1^tm1.1Itl Agrp^tm1(cre)Lowl/Agrp⁺	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	MGI:5543678
cn2	Agrp^tm1(cre)Lowl/Agrp⁺ Lepr^tm1.1Chua/Lepr^tm1.1Chua	involves: 129S6/SvEvTac	MGI:5142228
cn3	Agrp^tm1(cre)Lowl/Agrp⁺ Slc32a1^tm1Lowl/Slc32a1^tm1Lowl	involves: 129S6/SvEvTac * C57BL/6	MGI:3815087
cn4	Agrp^tm1(cre)Lowl/Agrp⁺ Slc32a1^tm1Lowl/Slc32a1^tm1Lowl Tg(Pomc1-hrGFP)1Lowl/0	involves: 129S6/SvEvTac * FVB/N	MGI:5142231
cn5	Agrp^tm1(cre)Lowl/Agrp⁺ Lepr^tm1.1Chua/Lepr^tm1.1Chua Tg(Pomc1-hrGFP)1Lowl/0	involves: 129S6/SvEvTac * FVB/N	MGI:5142229

Allelic Composition	Rock1^tm1.1Itl/Rock1^tm1.1Itl Agrp^tm1(cre)Lowl/Agrp⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^tm1(cre)Lowl mutation (1 available); any Agrp mutation (18 available)
Rock1^tm1.1Itl mutation (0 available); any Rock1 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:204885 )

increased epididymal fat pad weight ( J:204885 )

increased mesenteric fat pad weight ( J:204885 )

increased renal fat pad weight ( J:204885 )

• perirenal

growth/size/body

increased body weight ( J:204885 )

obese ( J:204885 )

Allelic Composition	Agrp^tm1(cre)Lowl/Agrp⁺ Lepr^tm1.1Chua/Lepr^tm1.1Chua
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^tm1(cre)Lowl mutation (1 available); any Agrp mutation (18 available)
Lepr^tm1.1Chua mutation (1 available); any Lepr mutation (121 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:174691 )

N	• no change in spontaneous IPSC amplitude or frequency is observed in Pomc1 neurons in slices

Allelic Composition	Agrp^tm1(cre)Lowl/Agrp⁺ Slc32a1^tm1Lowl/Slc32a1^tm1Lowl
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrp^tm1(cre)Lowl mutation (1 available); any Agrp mutation (18 available)
Slc32a1^tm1Lowl mutation (1 available); any Slc32a1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal inhibitory postsynaptic currents ( J:140858 )

• absent in AgRP neurons

growth/size/body

decreased body weight ( J:140858 )

• in both males and females on a normal chow diet

decreased susceptibility to diet-induced obesity ( J:140858 )

• decrease in weight gain when place on a high fat diet

adipose tissue

decreased total body fat amount ( J:140858 )

• decrease in weight gain on a high fat diet is solely the result of reduced fat accumulation

behavior/neurological

abnormal food intake ( J:140858 )

• attenuated response to gherlin induced increase in food intake

• however, no difference in baseline food intake is detected

increased locomotor activity ( J:140858 )

• increased locomotor activity

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:140858 )

• decrease in weight gain when place on a high fat diet

increased oxygen consumption ( J:140858 )

• on a normal chow diet

• during the transition from a normal chow diet to a high fat diet there is a larger increase in oxygen consumption compared to controls

decreased respiratory quotient ( J:140858 )

• reduced

Allelic Composition	Agrp^tm1(cre)Lowl/Agrp⁺ Slc32a1^tm1Lowl/Slc32a1^tm1Lowl Tg(Pomc1-hrGFP)1Lowl/0
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:174691 )

N	• addition of leptin produces similar inhibition of sIPSCs in neurons to that observed in control preparations

Allelic Composition	Agrp^tm1(cre)Lowl/Agrp⁺ Lepr^tm1.1Chua/Lepr^tm1.1Chua Tg(Pomc1-hrGFP)1Lowl/0
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:174691 )

N	• addition of leptin produces similar inhibition of sIPSCs in neurons to that observed in control preparations

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