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Six3tm4(cre/ERT2)Gco
Targeted Allele Detail
Nomenclature
Symbol: Six3tm4(cre/ERT2)Gco
Name: sine oculis-related homeobox 3; targeted mutation 4, Guillermo Oliver
MGI ID: MGI:3814875
Synonyms: Six3tm4(cre/Esr1)Gco
Gene: Six3  Location: Chr17:85613608-85629302 bp, + strand  Genetic Position: Chr17, 55.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140315
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    induced by tamoxifen
Mutation:    Insertion
 
Mutation details
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Six3     Summary of all recombinase alleles driven by Six3.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Six3 Mutation:  3 strains or lines available
References
Original:  J:140315 Geng X, et al., Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell. 2008 Aug;15(2):236-47
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory