Phenotypes associated with this allele

• Allele Symbol: Six3^{tm4(cre/ERT2)Gco}
• Allele Name: targeted mutation 4, Guillermo Oliver
• Allele ID: MGI:3814875
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Six3^tm4(cre/ERT2)Gco/Six3^+	involves: 129S1/Sv * C57BL/6	MGI:3814906

Genotype
MGI:3814906

ht1

• Allelic Composition: Six3^{tm4(cre/ERT2)Gco}/Six3⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

holoprosencephaly ( J:140315 )

• Background Sensitivity: 16% display a phenotype typical of holoprosencephaly after one backcross to C57BL/6

• Background Sensitivity: after two additional backcrosses to C57BL/6, 85% show a holoprosencephaly phenotype

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
holoprosencephaly 2		DOID:0110872	OMIM:157170	J:140315