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Targeted Allele Detail
Symbol: Fez1tm1Kei
Name: fasciculation and elongation protein zeta 1 (zygin I); targeted mutation 1, Keiichi I Nakayama
MGI ID: MGI:3811164
Gene: Fez1  Location: Chr9:36821864-36878924 bp, + strand  Genetic Position: Chr9, 20.69 cM
Germline Transmission:  Earliest citation of germline transmission: J:139974
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2, which contains the translation initiation codon, was replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:139974)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 22 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fez1 Mutation:  24 strains or lines available
Original:  J:139974 Sakae N, et al., Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants. Hum Mol Genet. 2008 Oct 15;17(20):3191-203
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory