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Transgene Detail
Symbol: Tg(Camk2a-ITM2B)8.4Ldad
Name: transgene insertion 8.4, Luciano D'Adamio
MGI ID: MGI:3810989
Synonyms: BRI2-8.4
Transgene: Tg(Camk2a-ITM2B)8.4Ldad  Location: unknown  
Strain of Origin:  FVB
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Camk2a-ITM2B)8.4Ldad expresses 1 gene
Mutation detailsAn approximately 8.5 kb genomic DNA fragment located upstream of the transcription initiation site of Camk2a including the transcription start site and 84 bp of the 5' noncoding exon is followed by a hybrid intron, a human ITM2B cDNA and an SV40 polyadenylation site. Two lines (8.4 and 5.5) were generated that differed in expression levels with line 8.4 having higher expression levels compared to line 5.5. This is a representative record for these 2 lines. (J:138796)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:138796 Matsuda S, et al., BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci. 2008 Aug 27;28(35):8668-76
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
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