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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Camk2a-ITM2B)8.4Ldad
transgene insertion 8.4, Luciano D'Adamio
MGI:3810989
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Itm2btm2.1Ldad/Itm2b+
Tg(Camk2a-ITM2B)8.4Ldad/0 		B6.Cg-Itm2btm2.1Ldad Tg(Camk2a-ITM2B)8.4Ldad MGI:4936848
cx2
 		Tg(Camk2a-ITM2B)8.4Ldad/0
Tg(PRNP-APPSweInd)8Dwst/0 		involves: C3H/HeJ * C57BL/6J * FVB/N MGI:3810992


Genotype
MGI:4936848
cx1
Allelic
Composition		 Itm2btm2.1Ldad/Itm2b+
Tg(Camk2a-ITM2B)8.4Ldad/0
Genetic
Background		 B6.Cg-Itm2btm2.1Ldad Tg(Camk2a-ITM2B)8.4Ldad
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm2.1Ldad mutation (0 available); any Itm2b mutation (18 available)
Tg(Camk2a-ITM2B)8.4Ldad mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:167154 )
N
• mice exhibit normal spatial working memory and novel object recognition




Genotype
MGI:3810992
cx2
Allelic
Composition		 Tg(Camk2a-ITM2B)8.4Ldad/0
Tg(PRNP-APPSweInd)8Dwst/0
Genetic
Background		 involves: C3H/HeJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:138796 )
• reduction in plaque formation compared to mice carrying just Tg(PRNP-APPSweInd)8Dwst

homeostasis/metabolism
amyloid beta deposits ( J:138796 )
• reduction in plaque formation compared to mice carrying just Tg(PRNP-APPSweInd)8Dwst




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory