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Targeted Allele Detail
Symbol: Itm2btm1.1Ldad
Name: integral membrane protein 2B; targeted mutation 1.1, Luciano D'Adamio
MGI ID: MGI:3810987
Synonyms: Bri2-
Gene: Itm2b  Location: Chr14:73362231-73385271 bp, - strand  Genetic Position: Chr14, 38.88 cM
Germline Transmission:  Earliest citation of germline transmission: J:138796
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA loxP site was inserted 200 bp 5' of exon 2 and a floxed PGK-neo cassette was inserted in intron 2 via homologous recombination. The floxed PGK-neo cassette and exon 2 were deleted via in vivo Cre-mediated recombination. Western blot analysis of brain membranes from homozygous mice confirmed the absence of protein expression. (J:138796)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itm2b Mutation:  3 strains or lines available
Original:  J:138796 Matsuda S, et al., BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci. 2008 Aug 27;28(35):8668-76
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory