Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm1.1Ldad mutation
(0 available);
any
Itm2b mutation
(18 available)
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behavior/neurological
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• mice spend the same time exploring a novel and familiar object introduced 24 hours prior unlike wild-type mice
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• mice exhibit impaired spatial working memory compared with wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm1.1Ldad mutation
(0 available);
any
Itm2b mutation
(18 available)
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nervous system
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• at 11 months of age levels of soluble APP-alpha and APP-beta are increased in the brain
• however, no obvious change in overall APP levels is detected
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm1.1Ldad mutation
(0 available);
any
Itm2b mutation
(18 available)
|
|
|
behavior/neurological
|
• mice spend equal time exploring novel and old objects unlike wild-type mice
|
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• mice exhibit impaired spatial working memory in a radial-arm water maze compared with wild-type mice
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nervous system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itm2btm1.1Ldad mutation
(0 available);
any
Itm2b mutation
(18 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation
(6 available)
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nervous system
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• obvious increase in soluble APP-alpha in brain homogenates
• significant increase in both Abeta40 and Abeta42 compared to mice wild-type for Itm2b
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