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Targeted Allele Detail
Symbol: Trpc3tm1.1Akon
Name: transient receptor potential cation channel, subfamily C, member 3; targeted mutation 1.1, Arthur Konnerth
MGI ID: MGI:3810122
Synonyms: Trpc3-
Gene: Trpc3  Location: Chr3:36674631-36744316 bp, - strand  Genetic Position: Chr3, 17.93 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:139695
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was introduced into intron 6 and a floxed PGK-neo cassette was inserted into intron 7. The selection cassette was removed from properly targeted ES cells leaving exon 7 floxed. Mice with the floxed exon 7 were crossed to cre expressing mice to create the knockout allele. (J:139695)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trpc3 Mutation:  32 strains or lines available
Original:  J:139695 Hartmann J, et al., TRPC3 channels are required for synaptic transmission and motor coordination. Neuron. 2008 Aug 14;59(3):392-8
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory