Phenotypes associated with this allele

• Allele Symbol: Trpc3^tm1.1Akon
• Allele Name: targeted mutation 1.1, Arthur Konnerth
• Allele ID: MGI:3810122
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpc3^tm1.1Akon/Trpc3^tm1.1Akon	involves: 129S/SvEv	MGI:5296036
hm2	Trpc3^tm1.1Akon/Trpc3^tm1.1Akon	involves: 129S/SvEv * 129S4/SvJaeSor	MGI:3810154

Genotype
MGI:5296036

hm1

• Allelic Composition: Trpc3^tm1.1Akon/Trpc3^tm1.1Akon
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye physiology ( J:176849 )

• intrinsically photosensitive retinal ganglion cells exhibit decreased firing frequency at most light intensities compared with wild-type cells

• however, sensitivity is normal

Genotype
MGI:3810154

hm2

• Allelic Composition: Trpc3^tm1.1Akon/Trpc3^tm1.1Akon
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor

behavior/neurological

impaired limb coordination ( J:139695 )

• reduced ability to walk on an irregularly spaced ladder or on a thin elevated beam

abnormal gait ( J:139695 )

• hind feet track outside of the path defined by the body diameter

nervous system

nervous system phenotype ( J:139695 )

N • normal size and layered structure of cerebellum

N • normal Purkinje cell morphology

abnormal excitatory postsynaptic currents ( J:139695 )

• the mGluR1 (Grm1) mediated slow EPSC is completely abolished

• synaptically evoked dendritic calcium ion signal is unaffected