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Id2tm1Ago
Targeted Allele Detail
Summary
Symbol: Id2tm1Ago
Name: inhibitor of DNA binding 2; targeted mutation 1, Ananda W Goldrath
MGI ID: MGI:3806370
Gene: Id2  Location: Chr12:25143798-25146091 bp, - strand  Genetic Position: Chr12, 8.57 cM, cytoband B
Alliance: Id2tm1Ago page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116119
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette in reverse orientation replaced upstream untranslated sequence and the helix-loop-helix dimerization domain in exon 1. Northern blot and RT-PCR analysis confirmed the absence of expression in fetal liver and P7 thymi, respectively. (J:116119)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Id2 Mutation:  19 strains or lines available
References
Original:  J:116119 Cannarile MA, et al., Transcriptional regulator Id2 mediates CD8(+) T cell immunity. Nat Immunol. 2006 Dec;7(12):1317-25
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory