Hand2tm1Majh
Targeted Allele Detail
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Symbol: |
Hand2tm1Majh |
Name: |
heart and neural crest derivatives expressed 2; targeted mutation 1, Marthe J Howard |
MGI ID: |
MGI:3804207 |
Synonyms: |
Hand2flneo, Hand2loxpneop |
Gene: |
Hand2 Location: Chr8:57774018-57777552 bp, + strand Genetic Position: Chr8, 29.8 cM
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Alliance: |
Hand2tm1Majh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:138032
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S1/SvImJ
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Allele Type: |
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Targeted (Conditional ready, Hypomorph) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1. Quanitative RT-PCR analysis of jaws from E11 embryos indicated that transcript expression in homozygous embryos was only about 14% that of wild-type littermates. Therefore, this allele is a hypomorph.
(J:137726, J:138032)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hand2 Mutation: |
12 strains or lines available
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Original: |
J:138032 Hendershot TJ, et al., Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system. Dev Dyn. 2007 Jan;236(1):93-105 |
All: |
3 reference(s) |
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