Phenotypes associated with this allele

• Allele Symbol: Hand2^tm1Majh
• Allele Name: targeted mutation 1, Marthe J Howard
• Allele ID: MGI:3804207
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hand2^tm1Majh/Hand2^tm1Majh	involves: 129S1/SvImJ	MGI:3804453

Genotype
MGI:3804453

hm1

• Allelic Composition: Hand2^tm1Majh/Hand2^tm1Majh
• Genetic Background: involves: 129S1/SvImJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137726 )

• embryos die around E12

• treatment of dams with a mixture of catecholamine intermediates allows mice to survive to birth

cardiovascular system

abnormal heart development ( J:137726 )

• in catecholamine rescued embryos at E14

craniofacial

abnormal craniofacial bone morphology ( J:137726 )

• in catecholamine rescued embryos at E14

short mandible ( J:137726 )

• in catecholamine rescued embryos at E14

cleft secondary palate ( J:137726 )

• cleft secondary palate at E18

embryo

decreased embryo size ( J:137726 )

• in catecholamine rescued embryos at E14

behavior/neurological

abnormal suckling behavior ( J:137726 )

• unable to suckle

nervous system

nervous system phenotype ( J:137726 )

N • unlike mice with conditional deletion of Hand2 in neural crest cells no significant reduction in the number of neurons is detected

skeleton

abnormal craniofacial bone morphology ( J:137726 )

• in catecholamine rescued embryos at E14

short mandible ( J:137726 )

• in catecholamine rescued embryos at E14

growth/size/body

cleft secondary palate ( J:137726 )

• cleft secondary palate at E18

decreased embryo size ( J:137726 )

• in catecholamine rescued embryos at E14

digestive/alimentary system

cleft secondary palate ( J:137726 )

• cleft secondary palate at E18