Kat2a^tm3.2Roth
Targeted Allele Detail

Summary

• Symbol: Kat2a^tm3.2Roth
• Name: K(lysine) acetyltransferase 2A; targeted mutation 3.2, Sharon Y R Dent
• MGI ID: MGI:3801276
• Synonyms: Gcn5^flox
• Gene: Kat2a Location: Chr11:100595572-100603291 bp, - strand Genetic Position: Chr11, 63.53 cM
• Alliance: Kat2a^tm3.2Roth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132940
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted downstream of exon 2 and an additional loxP site was inserted downstream of exon 18. Germ line, cre-mediated recombination was used to remove the neo cassette leaving exons 3 through 18 floxed. (J:132940)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kat2a Mutation: 40 strains or lines available

References

• Original: J:132940 Lin W, et al., Proper expression of the Gcn5 histone acetyltransferase is required for neural tube closure in mouse embryos. Dev Dyn. 2008 Apr;237(4):928-40
• All: 14 reference(s)