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Droshatm1Litt
Targeted Allele Detail
Nomenclature
Symbol: Droshatm1Litt
Name: drosha, ribonuclease type III; targeted mutation 1, Dan R Littman
MGI ID: MGI:3801076
Synonyms: DroshaF, DroshaflEx9, Droshalox
Gene: Drosha  Location: Chr15:12824863-12935243 bp, + strand  Genetic Position: Chr15, 5.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138683
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was used to introduce a loxP-flanked neomycin resistance cassette to intron 8, and an additional loxP site to intron 9 of the gene. The construct was electroporated into 129P2/OlaHsd-derived E14 embryonic stem (ES) cells. The neomycin cassette was excised with a C57BL/6 background EIIa-Cre, leaving loxP sites on either side of exon 9. (J:138683)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Drosha Mutation:  44 strains or lines available
References
Original:  J:138683 Chong MM, et al., The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med. 2008 Sep 1;205(9):2005-17
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory