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Bcl2l11tm4Rjd
Targeted Allele Detail
Nomenclature
Symbol: Bcl2l11tm4Rjd
Name: BCL2-like 11 (apoptosis facilitator); targeted mutation 4, Roger J Davis
MGI ID: MGI:3800472
Synonyms: BimdeltaEL, BimL-only
Gene: Bcl2l11  Location: Chr2:128126038-128162547 bp, + strand  Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137061
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette was inserted within intron 4, and genomic sequence with deleted alternatively spliced exon 3 was introduced by homologous recombination. Replaced mutation caused the entire exon 3, necessary for BimEL isoform transcription, to be deleted. The neo cassette was then excised with cre recombinase, leaving a single loxP site in intron 4. By immunoblot analyses, no BimEL proteins were expressed; however, increased amounts of BimL proteins was expressed. This is BimEL isoform specific knock-out allele. (J:137061)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bcl2l11 Mutation:  18 strains or lines available
References
Original:  J:137061 Hubner A, et al., Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell. 2008 May 23;30(4):415-25
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory