Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm4Rjd mutation
(1 available);
any
Bcl2l11 mutation
(32 available)
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cellular
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• increased serum withdrawal induced apoptosis of MEF cells in culture
• homozygous mutants were born from heterozygous crosses, the average litter size obtained from matings of homozygous mutant mice was normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm4Rjd mutation
(1 available);
any
Bcl2l11 mutation
(32 available)
|
|
|
hematopoietic system
N |
• normal numbers of white blood cells, splenocytes, thymocytes, lymphocytes, neutrophils, platelets, B cells and T cells
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immune system
N |
• normal numbers of white blood cells, splenocytes, thymocytes, lymphocytes, neutrophils, platelets, B cells and T cells
• double positive thymocytes exhibit normal sensitivity to apoptotic stimuli
• mice exhibit normal mitogenic activation of T and B cells
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