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Il21rtm1Kopf
Targeted Allele Detail
Nomenclature
Symbol: Il21rtm1Kopf
Name: interleukin 21 receptor; targeted mutation 1, Manfred Kopf
MGI ID: MGI:3800291
Synonyms: Il-21r-
Gene: Il21r  Location: Chr7:125603429-125633570 bp, + strand  Genetic Position: Chr7, 68.98 cM, cytoband F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137508
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 through 5 were replaced with a neo cassette. The absence of transcript was confirmed by RT-PCR on splenocyte extracts. (J:137508)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il21r Mutation:  25 strains or lines available
References
Original:  J:137508 Frohlich A, et al., IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo. Blood. 2007 Mar 1;109(5):2023-31
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory