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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il21rtm1Kopf
targeted mutation 1, Manfred Kopf
MGI:3800291
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il21rtm1Kopf/Il21rtm1Kopf B6.129-Il21rtm1Kopf MGI:3801614
hm2
 		Il21rtm1Kopf/Il21rtm1Kopf involves: 129/Sv * BALB/c MGI:3801613


Genotype
MGI:3801614
hm1
Allelic
Composition		 Il21rtm1Kopf/Il21rtm1Kopf
Genetic
Background		 B6.129-Il21rtm1Kopf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il21rtm1Kopf mutation (1 available); any Il21r mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased basophil cell number ( J:137508 )
• in blood and spleen when mice are infected with Heligmosomoides polygyrus
decreased eosinophil cell number ( J:137508 )
• in blood when mice are infected with Heligmosomoides polygyrus
impaired eosinophil recruitment ( J:137508 )
• reduced infiltration into airways when mice are infected with Nippostrongylus brasiliensis
abnormal lymphocyte physiology ( J:137508 )
• reduced infiltration into airways when mice are infected with Nippostrongylus brasiliensis
decreased IgA level ( J:137508 )
• in broncho-alveolar lavage fluid and in serum when mice are infected with Nippostrongylus brasiliensis
increased IgE level ( J:137508 )
• elevated 2 fold
decreased IgG1 level ( J:137508 )
• in broncho-alveolar lavage fluid and in serum when mice are infected with Nippostrongylus brasiliensis
abnormal T-helper 1 physiology ( J:137508 )
• normal Th1 response to Leishmania major infection
• lymphocyte restimulation leads to a greater increase in Ifn gamma producing CD4+ T cells
abnormal T-helper 2 physiology ( J:137508 )
• ability of Th2 cells in culture to produce Il4 and Ifn gamma is unaffected by Heligmosomoides polygyrus infection
• Il4 is reduced in the culture medium and Ifn gamma levels are increased when Th2 cells are from mice infected with Heligmosomoides polygyrus
increased susceptibility to experimental autoimmune encephalomyelitis ( J:137377 )
• increased susceptibility when injected with myelin oligodendrocyte glycoprotein
granulomatous inflammation ( J:137508 )
• intestinal granuloma formation is impaired in mice infected with Heligmosomoides polygyrus

hematopoietic system
decreased basophil cell number ( J:137508 )
• in blood and spleen when mice are infected with Heligmosomoides polygyrus
decreased eosinophil cell number ( J:137508 )
• in blood when mice are infected with Heligmosomoides polygyrus
impaired eosinophil recruitment ( J:137508 )
• reduced infiltration into airways when mice are infected with Nippostrongylus brasiliensis
abnormal lymphocyte physiology ( J:137508 )
• reduced infiltration into airways when mice are infected with Nippostrongylus brasiliensis
decreased IgA level ( J:137508 )
• in broncho-alveolar lavage fluid and in serum when mice are infected with Nippostrongylus brasiliensis
increased IgE level ( J:137508 )
• elevated 2 fold
decreased IgG1 level ( J:137508 )
• in broncho-alveolar lavage fluid and in serum when mice are infected with Nippostrongylus brasiliensis
abnormal T-helper 1 physiology ( J:137508 )
• normal Th1 response to Leishmania major infection
• lymphocyte restimulation leads to a greater increase in Ifn gamma producing CD4+ T cells
abnormal T-helper 2 physiology ( J:137508 )
• ability of Th2 cells in culture to produce Il4 and Ifn gamma is unaffected by Heligmosomoides polygyrus infection
• Il4 is reduced in the culture medium and Ifn gamma levels are increased when Th2 cells are from mice infected with Heligmosomoides polygyrus




Genotype
MGI:3801613
hm2
Allelic
Composition		 Il21rtm1Kopf/Il21rtm1Kopf
Genetic
Background		 involves: 129/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il21rtm1Kopf mutation (1 available); any Il21r mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:137377 )
N
• normal frequency of IFN gamma and IL17 producing CD4+ T cells when mice are immunized with an alpha myosin peptide
impaired eosinophil recruitment ( J:137508 )
• after intranasal OVA challenge of OVA immunized mice
abnormal lymphocyte physiology ( J:137508 )
• after intranasal OVA challenge of OVA immunized mice reduced proliferation of lymphocytes is seen
decreased IgA level ( J:137508 )
• of OVA specific IgA in broncho-alveolar lavage fluid and in serum
increased IgE level ( J:137508 )
• elevated 2 fold
decreased IgG1 level ( J:137508 )
• of OVA specific IgG1 in broncho-alveolar lavage fluid and in serum

hematopoietic system
impaired eosinophil recruitment ( J:137508 )
• after intranasal OVA challenge of OVA immunized mice
abnormal lymphocyte physiology ( J:137508 )
• after intranasal OVA challenge of OVA immunized mice reduced proliferation of lymphocytes is seen
decreased IgA level ( J:137508 )
• of OVA specific IgA in broncho-alveolar lavage fluid and in serum
increased IgE level ( J:137508 )
• elevated 2 fold
decreased IgG1 level ( J:137508 )
• of OVA specific IgG1 in broncho-alveolar lavage fluid and in serum




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory