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Targeted Allele Detail
Symbol: Wdr77tm1Zwan
Name: WD repeat domain 77; targeted mutation 1, Zhengxin Wang
MGI ID: MGI:3798419
Synonyms: p44-
Gene: Wdr77  Location: Chr3:105959498-105969760 bp, + strand  Genetic Position: Chr3, 46.46 cM
Germline Transmission:  Earliest citation of germline transmission: J:137003
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing part of exon 1 and exons 2 through 4 was replaced with a neo cassette. This results in ablation of amino acids 1 to 154. Reduction in protein expression was confirmed by western blot analysis on prostate extracts of heterozygous mice. (J:137003)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wdr77 Mutation:  7 strains or lines available
Original:  J:137003 Zhou L, et al., Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells. J Mol Endocrinol. 2006 Oct;37(2):283-300
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory