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Best2tm1Dgen
Targeted Allele Detail
Nomenclature
Symbol: Best2tm1Dgen
Name: bestrophin 2; targeted mutation 1, Deltagen
MGI ID: MGI:3796232
Synonyms: Best2tm1Amar
Gene: Best2  Location: Chr8:85007202-85014531 bp, - strand  Genetic Position: Chr8, 41.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:136137
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Project Collection: Deltagen
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 1 containing the translation initiation methionine through part of exon 3 was replaced with a lacZ-neo cassette. The absence of protein product was confirmed by immunohistochemistry of colon and eye tissue. This is a null allele and a reporter allele. (J:136137)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Best2 Mutation:  15 strains or lines available
References
Original:  J:136137 Bakall B, et al., Bestrophin-2 is involved in the generation of intraocular pressure. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1563-70
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory