All Phenotypes Best2<tm1Dgen> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Best2^tm1Dgen
targeted mutation 1, Deltagen
MGI:3796232

Summary

2 genotypes

Allelic Composition	Best2^tm1Dgen/Best2^tm1Dgen
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Best2^tm1Dgen mutation (0 available); any Best2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal intraocular pressure ( J:136137 )

• mice treated with timolol fail to exhibit a reduction in intraocular pressure unlike in similarly treated wild-type mice

ocular hypotension ( J:136137 )

• mice exhibit lower intraocular pressure compared to wild-type mice

• mice exhibit a greater reduction in intraocular pressure when treated with brinzolamide compared to similarly treated wild-type mice

taste/olfaction

taste/olfaction phenotype ( J:136137 )

N	• mice exhibit normal olfaction

digestive/alimentary system

digestive/alimentary phenotype ( J:136137 )

N	• mice do not exhibit gastrointestinal distress or diarrhea

homeostasis/metabolism

• mice exhibit a greater reduction in intraocular pressure when treated with brinzolamide compared to similarly treated wild-type mice

• mice treated with timolol fail to exhibit a reduction in intraocular pressure unlike in similarly treated wild-type mice

Allelic Composition	Best2^tm1Dgen/Best2⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Best2^tm1Dgen mutation (0 available); any Best2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal intraocular pressure ( J:136137 )

• mice treated with timolol fail to exhibit a reduction in intraocular pressure unlike in similarly treated wild-type mice

ocular hypotension ( J:136137 )

• mice exhibit a greater reduction in intraocular pressure when treated with brinzolamide compared to similarly treated wild-type mice

homeostasis/metabolism

• mice exhibit a greater reduction in intraocular pressure when treated with brinzolamide compared to similarly treated wild-type mice

• mice treated with timolol fail to exhibit a reduction in intraocular pressure unlike in similarly treated wild-type mice

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