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Targeted Allele Detail
Symbol: Bdkrb1tm2Bdr
Name: bradykinin receptor, beta 1; targeted mutation 2, Michael Bader
MGI ID: MGI:3790746
Synonyms: B1B2-
Gene: Bdkrb1  Location: Chr12:105604091-105605511 bp, + strand  Genetic Position: Chr12, 55.81 cM, cytoband F1
Germline Transmission:  Earliest citation of germline transmission: J:134859
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe coding region was replaced with a hygro cassette in ES cells containing Bdkrb2tm1Jfh. The absence of either transcript was confirmed by RT-PCR in stomach, ileum, kidney, heart, brain and lung extracts. (J:134859)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bdkrb1 Mutation:  12 strains or lines available
ES cells used were established from homozygous B6.129S7/SvBrd-Bdkrb2tm1Jfh mice. Also note the targeting vector used was identical to the one used to generate Bdkrb1tm1Bdr.
Original:  J:134859 Cayla C, et al., Mice deficient for both kinin receptors are normotensive and protected from endotoxin-induced hypotension. FASEB J. 2007 Jun;21(8):1689-98
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory