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Targeted Allele Detail
Symbol: Foxp3tm4(YFP/icre)Ayr
Name: forkhead box P3; targeted mutation 4, Alexander Y Rudensky
MGI ID: MGI:3790499
Synonyms: Foxp3Cre, Foxp3tm4(YFP/cre)Ayr, Foxp3YFP-Cre
Gene: Foxp3  Location: ChrX:7445915-7461482 bp, + strand  Genetic Position: ChrX, 3.41 cM
Germline Transmission:  Earliest citation of germline transmission: J:134513
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Mutation detailsA YFP/icre fusion construct with an upstream IRES element and a downstream frt-flanked neomycin resistance cassette was placed into the downstream untranslated region of the gene. Chimeric mice were crossed with FLPe expressing mice to remove the neomycin selection cassette. YFP-cre expression based on YFP flouresecene was only detected in regulatory T cells. Crossing these mice with mice that contain a cre-mediated reporter gene also demonstrated low level cre expression in about 2-10% of hematopoietic lineage cells including immature and mature B cells, T cells, myeloid cells and bone marrow precursor cells. (J:134513)
Generation of the Cd28tm1Ltu allele
 Tissue activity of this recombinase allele
Driver: Foxp3     Summary of all recombinase alleles driven by Foxp3. Comparative matrix view of recombinase activities

View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Foxp3 Mutation:  52 strains or lines available
Original:  J:134513 Rubtsov YP, et al., Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008 Apr;28(4):546-58
All:  244 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory