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Targeted Allele Detail
Symbol: Slco1b2tm1Cdk
Name: solute carrier organic anion transporter family, member 1b2; targeted mutation 1, Curtis D Klaassen
MGI ID: MGI:3785252
Gene: Slco1b2  Location: Chr6:141575244-141632372 bp, + strand  Genetic Position: Chr6, 72.57 cM, cytoband G1
Germline Transmission:  Earliest citation of germline transmission: J:133919
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 3 was disrupted by insertion of a floxed neo cassette. Low levels of a truncated mRNA transcript are detected. Western blot analysis confirmed the absence of protein in homozygous livers. Therefore, this is a null allele. (J:133919)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slco1b2 Mutation:  32 strains or lines available
Original:  J:133919 Lu H, et al., Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol Sci. 2008 May;103(1):35-45
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory